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Eugene W Gerner Selected Research

Sulindac (Copal)

8/2017Intermittent Dosing with Sulindac Provides Effective Colorectal Cancer Chemoprevention in the Azoxymethane-Treated Mouse Model.
1/2015Time-serial Assessment of Drug Combination Interventions in a Mouse Model of Colorectal Carcinogenesis Using Optical Coherence Tomography.
8/2011DFMO: targeted risk reduction therapy for colorectal neoplasia.
1/2011Targeting polyamines and inflammation for cancer prevention.
10/2010Ornithine decarboxylase-1 polymorphism, chemoprevention with eflornithine and sulindac, and outcomes among colorectal adenoma patients.
9/2010Levels of rectal mucosal polyamines and prostaglandin E2 predict ability of DFMO and sulindac to prevent colorectal adenoma.
11/2009Polyamines as mediators of APC-dependent intestinal carcinogenesis and cancer chemoprevention.
3/2009Risk of cardiovascular events in a randomized placebo-controlled, double-blind trial of difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas.
2/2009Combination chemoprevention for colon cancer targeting polyamine synthesis and inflammation.
12/2008Longitudinal assessment of air conduction audiograms in a phase III clinical trial of difluoromethylornithine and sulindac for prevention of sporadic colorectal adenomas.
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Eugene W Gerner Research Topics

Disease

40Neoplasms (Cancer)
11/2018 - 05/2002
24Carcinogenesis
11/2018 - 08/2002
24Colonic Neoplasms (Colon Cancer)
11/2018 - 07/2002
20Adenoma (Adenomas)
01/2014 - 06/2003
17Colorectal Neoplasms (Colorectal Cancer)
08/2017 - 02/2005
6Adenomatous Polyposis Coli (Familial Adenomatous Polyposis)
04/2010 - 05/2002
5Inflammation (Inflammations)
03/2013 - 02/2009
5Polyps
01/2011 - 07/2002
4Prostatic Neoplasms (Prostate Cancer)
01/2014 - 05/2002
3Adenomatous Polyps
07/2012 - 06/2008
3Ototoxicity
10/2010 - 12/2008
2Obesity
03/2013 - 10/2012
2Carcinoma (Carcinomatosis)
06/2008 - 02/2005
2Glioblastoma (Glioblastoma Multiforme)
10/2007 - 08/2007
1Neuroblastoma
01/2015
1Cardiovascular Diseases (Cardiovascular Disease)
01/2014
1Neoplasm Metastasis (Metastasis)
07/2013
1Pancreatic Neoplasms (Pancreatic Cancer)
07/2013
1B-Cell Lymphoma (Lymphoma, B Cell)
02/2010
1Adenocarcinoma
05/2009
1Lung Neoplasms (Lung Cancer)
05/2009
1Metabolic Syndrome (Dysmetabolic Syndrome X)
04/2009
1Hearing Loss (Hearing Impairment)
12/2008
1Stomach Neoplasms (Stomach Cancer)
06/2008

Drug/Important Bio-Agent (IBA)

40PolyaminesIBA
11/2018 - 05/2002
14Eflornithine (Ornidyl)FDA Link
11/2018 - 04/2004
14Sulindac (Copal)FDA LinkGeneric
08/2017 - 01/2006
10Ornithine Decarboxylase (Decarboxylase, Ornithine)IBA
01/2014 - 05/2002
10EnzymesIBA
07/2012 - 05/2002
9Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
11/2018 - 06/2003
9Pharmaceutical PreparationsIBA
01/2015 - 11/2005
6Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
10/2010 - 06/2003
6Proteins (Proteins, Gene)FDA Link
08/2010 - 05/2002
4PutrescineIBA
01/2014 - 01/2006
4SpermineIBA
10/2007 - 02/2005
3Caveolin 1IBA
07/2013 - 12/2008
3Biomarkers (Surrogate Marker)IBA
06/2011 - 02/2008
3Genetic Markers (Genetic Marker)IBA
11/2009 - 06/2003
3N(1),N(11)-diethylnorspermineIBA
10/2007 - 02/2005
3SpermidineIBA
06/2007 - 02/2005
3Arginine (L-Arginine)FDA Link
02/2007 - 02/2006
3RNA (Ribonucleic Acid)IBA
02/2007 - 08/2002
2Drug CombinationsIBA
11/2018 - 01/2015
2Biological ProductsIBA
08/2017 - 01/2015
2OrnithineIBA
01/2014 - 10/2010
2beta CateninIBA
04/2010 - 05/2009
2CarcinogensIBA
12/2008 - 04/2004
2PlacebosIBA
12/2008 - 06/2008
2Kallikreins (Kallikrein)IBA
06/2008 - 02/2008
2Peptide Hydrolases (Proteases)FDA Link
06/2008 - 02/2008
2Celecoxib (Celebrex)FDA Link
01/2008 - 02/2007
2Fluorouracil (Carac)FDA LinkGeneric
09/2006 - 02/2005
2Drinking WaterIBA
02/2006 - 04/2004
2Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
11/2003 - 07/2002
2Cyclooxygenase 2 (Cyclooxygenase-2)IBA
08/2002 - 07/2002
1AzoxymethaneIBA
08/2017
1Antineoplastic Agents (Antineoplastics)IBA
01/2015
1Untranslated RNA (Noncoding RNA)IBA
02/2014
1MicroRNAs (MicroRNA)IBA
02/2014
1Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
01/2014
1Interleukin-8 (Interleukin 8)IBA
07/2013
1Firefly LuciferasesIBA
07/2013
1Deoxyribonuclease I (Nickase)IBA
07/2013
1DNA (Deoxyribonucleic Acid)IBA
07/2013
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
03/2013
1Fibroblast Growth Factor 1 (FGF-1)IBA
03/2013
1Insulin (Novolin)FDA Link
03/2013
1Dietary FiberFDA Link
07/2012
1Ursodeoxycholic Acid (Urso)FDA LinkGeneric
07/2012
1Prostate-Specific Antigen (Semenogelase)IBA
01/2011
1Amino Acid Transport Systems (Amino Acid Transporter)IBA
01/2011
1Dinoprostone (PGE2)FDA Link
09/2010
1Vitamin DFDA LinkGeneric
04/2010
1Calcitriol Receptors (Calcitriol Receptor)IBA
04/2010
1LigandsIBA
04/2010
1Spermidine SynthaseIBA
02/2010
1Transcription Factors (Transcription Factor)IBA
10/2009
1ChromatinIBA
10/2009
1Deoxycholic Acid (Sodium Deoxycholate)IBA
05/2009
1(N(1),N(12))bis(ethyl)- 6,7- dehydrospermineIBA
05/2009
1CholesterolIBA
04/2009
1Glucose (Dextrose)FDA LinkGeneric
04/2009
1Codon (Codons)IBA
07/2008
1GTP Phosphohydrolases (GTPases)IBA
07/2008
1Dynamins (Dynamin)IBA
07/2008
1Messenger RNA (mRNA)IBA
06/2008
1TrypsinIBA
06/2008
1matrigelIBA
06/2008
1Laminin (Merosin)IBA
06/2008
1Serine (L-Serine)FDA Link
06/2008
1TOR Serine-Threonine KinasesIBA
10/2007
1Phosphatidylinositols (Phosphatidylinositol)IBA
10/2007

Therapy/Procedure

22Chemoprevention
08/2017 - 07/2002
6Drug Therapy (Chemotherapy)
11/2018 - 02/2005
5Therapeutics
01/2015 - 02/2005
5Aftercare (After-Treatment)
10/2012 - 12/2006
1Caloric Restriction
03/2013
1Secondary Prevention
08/2012
1Duration of Therapy
01/2011
1Endoscopes
11/2007